Methods of treating and preventing bone loss
OwnerJohn Allard, Robert Klein +1inventors
InventorsJohn Allard, Robert Klein, Gary Peltz
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Abstract
Methods of treating and preventing bone loss and/or enhancing bone formation are disclosed. The methods utilize 15-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with agents which inhibit bone resorption or additional agents that regulate calcium resorption from bone or enhances bone accumulation. The invention additionally provides methods of diagnosing a predisposition to bone loss.
Claims11
1-12. (canceled)
A method for identifying compounds that increase bone mineral density, the method comprising contacting a compound with 15-LO and determining whether the compound inhibits 15-LO.
A method for identifying compounds that increase bone mineral density, the method comprising contacting an inhibitor of 15-lipoxygenase with human mesenchymal stem cells and determining cellular differentiation into bone forming cells.
22-28. (canceled)
Dependencies are inferred from the claim text.