Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases

A compound having the formula CA1:

• or a pharmaceutically acceptable salt or ester thereof;
• wherein:
• X is H, —OH, or a halogen;
• n is 1, 2, or 3;
• R1-R5, independently of one another and other R groups, are selected from the group consisting of a hydrogen, a halogen, a —CN, —OR, —COOR, —OCOOR, —COR, —CON(R)2, —OCON(R)2, —N(R)2, —NO2, —SR, —SO2R, —SO2N(R)2 or —SOR group, an optionally substituted alkyl group, an optionally substituted alkenyl group, and an optionally substituted aryl group, where each R, independent of any other R in any listed group, is selected from H, an optionally substituted alkyl group and an optionally substituted aryl group, an optionally substituted acyl group;
• two or more of R1-R5 can together form one or more rings which may contain one or more double bonds or which may be aromatic;
• and
• R6 and R7, independently of each other and other R6 and R7 in the compound, are selected from the group consisting of a hydrogen, a halogen, a —N(R)2, or —SR group, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkoxy group, and an optionally substituted aryl group, where each R, independent of any other R in any listed group, is selected from H, an optionally substituted alkyl group and an optionally substituted aryl group;
• and
• wherein R6 and R7 can together form a ring which may contain one or more double bonds.