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US 2006/0079486 A1Published application
Lipopolymer conjugates
OwnerSamuel Zalipskyinventor
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Abstract
Conjugates of formula I, below, are useful in biomedicinal applications such as delivery of drugs or labeling moieties or as components of liposomes or micelles. In formula I, A is a hydrophilic polymer, each of L and L′ is independently a linker group, B is a lipid moiety; and Z is a diagnostic ligand, a biologically relevant ligand, or a reactive linking moiety, which is generally linked to the phosphorus atom of the conjugate via a nitrogen, oxygen or sulfur atom in Z.
Claims24
A compound of the formula:
- where
- A is a hydrophilic polymer;
- each of L and L′ is independently a linker group;
- B is a lipid moiety;
- and
- Z is selected from the group consisting of a diagnostic ligand, a biologically relevant ligand, and a reactive linking moiety, wherein said reactive linking moiety is not hydroxy (—OH), oxide (—O−), or 2-aminoethoxy.
3 more elements
A method of tailoring the hydrophilic-lipophilic balance of a carrier for a drug, comprising
- providing a carrier of the formula
- where
- A is a hydrophilic polymer,
- each of L and L′ is independently a linker group;
- B is a lipid moiety;
- and
- Z is said drug or a reactive moiety effective to be conjugated to said drug, wherein said reactive moiety is not hydroxy (—OH), oxide (—O−), or 2-aminoethoxy;
- and wherein the relative size of A and B is effective to give a desired HLB for said carrier.
5 more elements
A method for oral delivery of a therapeutic agent, comprising
- administering orally to a subject a conjugate of the formula I:
- where
- A is a hydrophilic polymer;
- each of L and L′ is independently a linker group;
- B is a lipid moiety;
- and
- Z comprises said therapeutic agent.
4 more elements
Dependencies are inferred from the claim text.