Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors

A compound of general Formula I

• or a pharmaceutically acceptable salt or solvate thereof, or a solvate of such a salt,
• wherein:
• R1 is selected from the group consisting of:
• C1-C6 alkyl, substituted with one or more basic groups, wherein the conjugate acid of said basic group has a pKa of from 1 to 15;
• cycloalkyl, substituted with one or more basic groups, wherein the conjugate acid of said basic group has a pKa of from 1 to 15;
• aromatic heterocyclyl, containing at least one nitrogen atom and substituted with one or more basic groups, wherein the conjugate acid of said basic group has a pKa of from 1 to 15;
• aliphatic heterocyclyl, containing at least one nitrogen atom;
• heterocyclyl, containing at least one hetero atom selected from S or O, and substituted with one or more basic groups, wherein the conjugate acid of said basic group has a pka of from 1-15;
• and
• aryl, substituted with one or more basic groups, wherein the conjugate acid of said basic group has a pKa of from 1 to 15;
• R2 is selected from the group consisting of H, methyl, halogen, and hydroxy;
• R3 is selected from the group consisting of COOR5, SO(OR5), SO3R5, P═O(OR5)2, B(OR5)2, P═OR5(OR5), tetrazole, and a carboxylic acid isostere;
• R4 represents a
• R5 is H, C1-C6 alkyl, or aryl;
• R6 is C1-C6 alkyl, aryl, cycloalkyl, heterocyclyl, or an optionally N-substituted
• H2N—C(Z)-CONH—C(Z)- or H2N—C(Z)- group;
• R7 is H or C1-C6 alkyl;
• X is C(Z)2;
• Y is C(Z)2 or a single bond;
• Z is independently selected from the group consisting of H, C1-C6 alkyl, aryl, cycloalkyl, and heterocyclyl.