High affinity nucleic acid ligands of complement system proteins
AssigneeGilead Sciences, Inc.
InventorsGregory Biesecker, Larry Gold
Life of this patent
Estimating the term…
Abstract
Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.
Claims3
A method for treating a Complement System-mediated disease comprising administering to a patient in need thereof a pharmaceutically effective amount of a Nucleic Acid Ligand of a Complement System Protein selected from the group consisting of C1q, C3 and C5;
- said Nucleic Acid Ligand selected from the group consisting of SEQ ID NOS:
- 75, 160-196.
Dependencies are inferred from the claim text.