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US 2006/0079462 A1Published application
Organoselenium compounds for cancer chemoprevention
AssigneeLKT Laboratories, Inc.
InventorsLuke Lam, Nayaz Ahmed
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Abstract
A compound containing an alkylene selenocyanate or an alkylene isoselenocyanate moiety effective to prevent the occurrence or progression of cancer or a precancerous condition. The compound can be provided and administered in the form of a pharmaceutical composition, a cosmetic, a food additive, supplement, or the like. Methods for synthesis and use of the chemopreventive compound of the invention are also provided.
Claims24
A cysteine-containing conjugate of a compound having formula I
- R1 is H, (alkylene)-SeCN, or a blocking group;
- R2 is H, (alkylene)-SeCN, or a blocking group;
- R3 is H, (alkylene)-SeCN, or a blocking group;
- R4 is (alkylene)-SeCN;
- and
- Z is S, Se or O;
- with the proviso that when R1═R4═CH2—SeCN, at least one of R2 and R3 is not H.
4 more elements
A cysteine-containing conjugate of a compound having formula II
- wherein:
- R1 is H, (alkylene)-NCSe, or a blocking group;
- R2 is H, (alkylene)-NCSe, or a blocking group;
- R3 is H, (alkylene)-NCSe, or a blocking group;
- R4 is (alkylene)-NCSe;
- and
- Z is S, Se, or O.
4 more elements
A compound having formula I
- wherein:
- R1 is H, (alkylene)-SeCN, or a blocking group;
- R2 is H, (alkylene)-SeCN, or a blocking group;
- R3 is H, (alkylene)-SeCN, or a blocking group;
- R4 is (alkylene)-SeCN;
- and
- Z is S, Se or O;
- wherein the cyanate group (—CN) of at least one (alkylene)-SeCN moiety is replaced with R5 wherein R5 is a cysteine, a derivatized cysteine or a peptide comprising cysteine, and wherein the sulfur atom of the cysteine is covalently linked to the selenium atom;
- with the proviso that when R1═R4═CH2—SeCN, at least one of R2 and R3 is not H.
6 more elements
A compound having formula II
- wherein:
- R1 is H, (alkylene)-NCSe, or a blocking group;
- R2 is H, (alkylene)-NCSe, or a blocking group;
- R3 is H, (alkylene)-NCSe, or a blocking group;
- R4 is (alkylene)-NCSe;
- and
- Z is S, Se or O;
- wherein the isoselenocyanate group (—NCSe) of at least one (alkylene)-NCSe moiety is replaced with —N(H)C(Se)R5 wherein R5 is a cysteine, a derivatized cysteine or a peptide comprising cysteine, such that the sulfur atom of the cysteine is covalently linked to the carbon atom of the at least one (alkylene)-NCSe moiety.
5 more elements
Dependencies are inferred from the claim text.