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US 2006/0079459 A1Published application
Stabilized compositions comprising tissue factor pathway inhibitor protein or tissue factor pathway inhibitor variant proteins
AssigneeChiron Corporation
InventorsBao-Lu Chen, Chin-Yi Huang
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Abstract
Stabilized aqueous compositions of tissue factor pathway inhibitor (TFPI) or TFPI variants comprise a solubilizing agent, an antioxidant, and a buffer. The combination of a solubilizing agent and an antioxidant can lead to a significant improvement in the storage life of TFPI or TFPI variant compositions. The solubilizing agent and antioxidant substantially counteract the effects of TFPI or TFPI variant degradation through aggregation and oxidation.
Claims32
An aqueous composition comprising:
- Tissue Factor Pathway Inhibitor (TFPI) or a variant thereof having about 70% or greater amino acid sequence identity to SEQ ID NO:1;
- arginine in an amount sufficient to stabilize said TFPI or variant thereof;
- and
- methionine in a concentration from 2 mM to 10 mM in said composition.
1 more element
Dependencies are inferred from the claim text.