BAFF, inhibitors thereof and their use in the modulation of B-cell response
AssigneeBiogen Idec MA Inc.
InventorsJeffrey Browning, Christine Ambrose, Fabienne MacKay, Jurg Tschopp, Pascal Schneider
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Abstract
The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
Claims9
1-50. (canceled)
A method of treating an immunodeficiency comprising administering to an individual, a therapeutically effective amount of a protein consisting of amino acids 134-285 of SEQ ID NO:1.
A method of treating an immunodeficiency comprising administering to an individual, a therapeutically effective amount of a protein comprising amino acids 134-285 of SEQ ID NO:1.
A method of treating an immunodeficiency comprising administering to an individual, a therapeutically effective amount of a protein consisting of an amino acid sequence which is 90% or more identical to amino acids 134-285 of SEQ ID NO:1, wherein the protein having said first amino acid sequence stimulates B lymphocyte proliferation, differentiation, or survival.
A method of treating an immunodeficiency comprising administering to an individual, a therapeutically effective amount of a protein comprising an amino acid sequence which is 90% or more identical to amino acids 134-285 of SEQ ID NO:1, wherein the protein stimulates B lymphocyte proliferation, differentiation, or survival.
Dependencies are inferred from the claim text.