Inhibition of Smad3 to prevent fibrosis and improve wound healing
OwnerAnita Roberts, Gillian Ashcroft +2inventors
InventorsAnita Roberts, Gillian Ashcroft, Angelo Russo, James Mitchell
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Abstract
The invention is related to modulation of Smad3 expression to prevent fibrosis and improve wound healing. Aspects of the invention, for example, include approaches to improve wound healing and/or reduce or prevent fibrosis by inhibiting Smad3. Embodiments described herein also include approaches to identify componds that modulate Smad3 expression and the preparation of pharmaceuticals comprising said compounds.
Claims21
-26. (canceled)
A method of identifying a Smad3 inhibitor that is suitable for improvement of wound healing, which wound healing is mediated by endogenous Smad3, comprising the steps of:
- a) exposing a cell-based system, which expresses Smad3, to the Smad3 inhibitor;
- b) measuring the effect on wound healing;
- and
- c) comparing the effect on wound healing of the cell-based system, which expresses Smad3, exposed to the test Smad3 inhibitor, to the effect on wound healing of a control cell-based system, so that a Smad3 inhibitor that is suitable for improvement of wound healing is identified.
A method of identifying a Smad3 inhibitor that is suitable for improvement of wound healing, which wound healing is mediated by endogenous Smad3, comprising the steps of:
- a) exposing a non-human animal model-based system, which expresses Smad3, to the Smad3 inhibitor;
- b) measuring the effect on wound healing;
- and
- c) comparing the effect on wound healing of the non-human animal model-based system, which expresses Smad3, exposed to the test Smad3 inhibitor, to the effect on wound healing of a control non-human animal model-based system, so that a Smad3 inhibitor that is suitable for improvement of wound healing is identified.
A method of identifying a Smad3 inhibitor that is suitable for protection against radiation-induced fibrosis, which fibrosis is mediated by endogenous Smad3, comprising the steps of:
- a) exposing a cell-based system, which expresses Smad3, to the Smad3 inhibitor;
- b) measuring the effect on radiation-induced fibrosis;
- and
- c) comparing the effect on radiation-induced fibrosis of the cell-based system, which expresses Smad3, exposed to the test Smad3 inhibitor, to the effect on radiation-induced fibrosis, of a control cell-based system, so that a Smad3 inhibitor that is suitable for protection against radiation-induced fibrosis is identified.
A method of identifying a Smad3 inhibitor that is suitable for protection against radiation-induced fibrosis, which radiation-induced fibrosis is mediated by endogenous Smad3, comprising the steps of:
- a) exposing a non-human animal model-based system, which expresses Smad3, to the Smad3 inhibitor;
- b) measuring the effect on radiation-induced fibrosis;
- and
- c) comparing the effect on radiation-induced fibrosis of the non-human animal model-based system which expresses Smad3, exposed to the test Smad3 inhibitor, to the effect on radiation-induced fibrosis of a control non-human animal model-based system, so that a Smad3 inhibitor that is suitable for protection against radiation-induced fibrosis is identified.
Dependencies are inferred from the claim text.