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US 2006/0078624 A1Published application
Microparticles and nanoparticles containing a lipopolymer
OwnerSamuel Zalipsky, Joyce Wonginventors
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Abstract
Microparticle and nanoparticles comprised of a polymer and of a lipid-polymer conjugate (lipopolymer) are described. The particles can include a therapeutic or diagnostic agent and/or a ligand attached to the lipopolymer. Compositions comprising the particles and methods of treatment using the particles are also described.
Claims23
A nanoparticle or microparticle comprised of a biodegradable polymer and of a first lipid-hydrophilic polymer-ligand conjugate, said conjugate incorporated into the nanoparticle or microparticle to provide an outer surface coating of hydrophilic polymer chains.
A method for delivering an agent to a subject, comprising
- administering to the subject a composition comprising nanoparticles or microparticles comprised of an agent, a biodegradable polymer, and a first lipid-hydrophilic polymer-ligand conjugate, said conjugate stably incorporated into the nanoparticles or microparticles to provide an outer surface coating of hydrophilic polymer chains and a ligand for interaction with a binding partner.
Dependencies are inferred from the claim text.