Method for the preparatin of paclitaxel solid dispersion by using the supercritical fluid process and paclitaxel solid dispersion prepared thereby

A method for the preparation of a highly uniform nano-scale paclitaxel solid dispersion by a supercritical fluid process which comprises:

• 1) preparing a mixture of paclitaxel and a pharmaceutically acceptable additive and dissolving in a mixed organic solvent to obtain a solution mixture;
• 2) forming particles of the mixture of paclitaxel and the pharmaceutically acceptable additive by spraying the solution mixture of Step 1) to the supercritical fluid to bring into contact with each other;
• 3) removing the organic solvent by washing the particles with a fresh batch of the supercritical fluid;
• and
• 4) recovering the particles prepared thereby.