Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof
AssigneeLTS Lohmann Therapie-Systeme AG
InventorWalter Muller
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Abstract
The invention relates to a transdermal therapeutic system (TTS) comprising at least one pharmacological active substance, which is suitable for heating up to a temperature above skin temperature, thereby promoting the permeation rate of the active substance. The transdermal therapeutic system comprises at least one layer containing the active substance and one peelable backing layer, and is characterize in that the layer containing the active substance mainly consists of a polysiloxane in which the active substance is partially dissolved.
Claims17
A transdermal therapeutic system (TTS) for administering at least one pharmacological active substance at a temperature which is above skin temperature, comprising at least one active substance-impermeable backing layer, at least one matrix layer which is based on at least one polysiloxane and contains at least one pharmacological active substance, a detachable protective layer, and an internal and/or external heating element, characterized in that
- a) the active substance-containing layer comprises, not taking the active substance into account, at least 80% by weight of at least one polysiloxane,
- b) not more than 20% by weight of active substance is present in dissolved form, and
- c) the active substance has a saturation solubility of not more than 5% by weight in the polysiloxane.
Dependencies are inferred from the claim text.