Use of glutamate and/or a glutamate precursor for the preparation of a nutritional or pharmaceutical preparation for the treatment or prevention of hyperpermeability or undesired permeability of the intestinal wall

(canceled)

Preparation containing free glutamate and/or a glutamate precursor and polyamines, in particular spermine, spermidine or putrescine and/or one or more polyamine precursors, in particular ornithin and arginin.

A method for treatment for deterioration of a mucosal barrier, an intestinal dysfunction or injury, suboptimal intestinal wall maturation of new-borns, undernutrition, suboptimal intestinal blood flow, allergy, sepsis, translocation of pathogenic bacteria through an intestinal wall, endotoxaemia, or viral diarrhoea, said method comprising orally or enterally administering to a patient in need of said treatment an effective amount of an exogenous nutritional preparation consisting essentially of at least one of free glutamic acid and α-keto acid.

A method for the treatment against hyperpermeability or regarding permeability of the intestinal wall in a person suffering from reduced intestinal glutaminase activity, said method comprising administering to a person in need of said treatment an effective amount of a nutritional preparation comprising at least one of free glutamic acid and α-keto glutaric acid.