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OwnerTheodore Randolph, Corinne Lengsfeld +1inventors
InventorsTheodore Randolph, Corinne Lengsfeld, Daniel Jarmer
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The invention provides methods of modifying the crystal habit of a compound without altering the crystal structure of the compound through a controlled precipitation technique in the presence of a crystal growth inhibitor as well as the crystallized compounds formed by these methods. Using these methods, the crystal habit of the compound may be modified from acicular to bipyramidal. The modification in crystal habit is attributable to a preferential adsorption mechanism of the crystal growth inhibitor to a fast growing crystal face of the compound. Powder flow properties of the crystallized product are significantly enhanced with the habit modification. This selective crystal habit modification using a crystal growth inhibitor provides a strategy to circumvent the manufacturing difficulties associated with acicular crystal habits, and may increase the manufacturing capability of supercritical fluid based crystallization and precipitation technologies.
A method comprising contacting a solvent comprising a compound and a crystal growth inhibitor, with an anti-solvent to extract the solvent from a co-precipitate of the compound and the crystal growth inhibitor.
An article of manufacture comprising a co-precipitate of a crystalline compound and a crystal growth inhibitor.
A pharmaceutical formulation comprising a co-precipitate of a crystalline compound and a crystal growth inhibitor.
A pharmaceutical formulation comprising a co-precipitate of griseofulvin and poly (sebacic anhydride).
A co-precipitate of a crystalline compound and a crystal growth inhibitor comprising contacting a solvent comprising a compound and a crystal growth inhibitor, with an anti-solvent to extract the solvent from a co-precipitate of the compound and the crystal growth inhibitor.
Dependencies are inferred from the claim text.