Porcine fgl2
OwnerGary Levy, Anand Ghanekar +1inventors
InventorsGary Levy, Anand Ghanekar, David Grant
Life of this patent
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Abstract
The present invention relates to porcine fgl2 gene and protein and methods of modulating the gene and protein. The methods are useful in preventing thrombosis associated with the xenotransplantation of porcine organs or tissues.
Claims19
A method of inhibiting or suppressing an immune response to a porcine organ or tissue comprising administering an effective amount of an agent that inhibits porcine fql2 to the porcine organ or tissue, porcine donor or transplant recipient.
A method of inhibiting or preventing thrombosis associated with xenotransplant rejection of a porcine organ or tissue comprising administering an effective amount of an agent that inhibits porcine fgl2 to the porcine organ or tissue, porcine donor or transplant recipient.
A method of modulating an immune response comprising administering an effective amount of a porcine fgl2 nucleic acid sequence, a porcine fgl2 protein or a porcine fgl2 modulator to an animal in need thereof.
An isolated porcine fgl2 nucleic acid molecule having a nucleic acid sequence shown in FIG. 1A (SEQ ID NO:1) or a homolog or analog thereof.
An isolated porcine fgl2 protein having an amino acid sequence shown in FIG. 1B (SEQ ID NO:2) or an analog, homolog or fragment thereof.
Dependencies are inferred from the claim text.