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US 2006/0078540 A1Published application
Dendritic cell nodes
OwnerWilliam Warren, Nir Hacohen +5inventors
InventorsWilliam Warren, Nir Hacohen, Lan Chen, Darell Irvine, Anatoly Kachurin, Russell Higbee, Qian Huang
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Abstract
The present invention features dendritic cell nodes that can be used to vaccinate subjects against pathogens and to modulate a subject's immune system to treat or prevent various diseases and conditions.
Claims6
A dendritic cell node comprising:
- a) a biocompatible scaffold material;
- b) a chemokine for attracting immature dendritic cells;
- c) a chosen antigen;
- and
- d) a maturation signal for dendritic cells.
2 more elements
2-25. (canceled)
A method of constructing a dendritic cell node comprising:
- a) depositing, onto a substrate, a layer for attracting monocytes into the dendritic cell node;
- b) depositing, onto layer (a), a layer for inducing differentiation of the monocytes into immature dendritic cells;
- c) depositing, onto layer (b), a layer for presenting a chosen antigen to immature dendritic cells;
- d) depositing, onto layer (c), a layer for attracting dendritic cells and inducing maturation of dendritic cells, thereby constructing a dendritic cell node.
1 more element
(canceled)
A method of constructing a dendritic cell node comprising:
- a) depositing, onto a substrate, a layer for attracting immature dendritic cells into the dendritic cell node;
- b) depositing, onto layer (a), a layer for presenting a chosen antigen to the immature dendritic cells;
- and
- c) depositing, onto layer (b), a layer for attracting immature dendritic cells and inducing maturation of the immature dendritic cells;
- or
- d) depositing, onto a substrate, a layer for attracting immature dendritic cells and inducing maturation of the immature dendritic cells;
- e) depositing, onto layer (d), a layer for presenting a chosen antigen to the immature dendritic cells;
- and
- f) depositing, onto layer (e), a layer for attracting immature dendritic cells into the dendritic cell node, thereby constructing an dendritic cell node.
6 more elements
29-47. (canceled)
Dependencies are inferred from the claim text.