Solid-phase preparation of [18f] fluorohaloalkanes
AssigneeHammersmith Imanet Limited
InventorsFrank Brady, Sajinder Luthra, Yongjun Zhao
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Abstract
The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I) wherein n is an integer of from (1) to (7) and X is chloro, bromo or iodo; with 18F− to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)nX (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F−, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.
Claims7
A process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I):
- SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I)
- wherein n is an integer of from 1 to 7 and X is chloro, bromo or iodo;
- with 18F− to produce the [18F]fluorohaloalkane of formula (II)
- 18F—(CH2)n—X (II)
- wherein n and X are as defined for the compound of formula (I), optionally followed by
- (i) removal of excess 18F−, for example by ion-exchange chromatography;
- and/or
- (ii) removal of organic solvent.
Dependencies are inferred from the claim text.