New process
OwnerKjell Andersson, Alan Fischer +4inventors
InventorsKjell Andersson, Alan Fischer, Panagiotis Ioannidis, Magnus Larsson, Maria Larsson, Sivaprasad Sivadasan
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Abstract
The present invention relates to novel resolution methods, which are useful in the preparation of enantiomerically enriched intermediates which in their turn are useful in the prepartion of compounds with a pharmacological effect on the insulin resistance syndrome (IRS). It is such a process that the present inventions sets out to define, and more particularly for the preparation of the (S)-enantioner of certain 2-ethoxy-3-(4-hydroxyphenyl)propanoic acids and derivatives thereof.
Claims10
1-21. (canceled)
A process for the preparation of a compound of formula VIII
- wherein Q is a protecting group selected from acetyl and C1-3 alkyl, and A is OH, a chiral auxiliary group or the group ORp, wherein Rp is a protecting group, and one or more of the hydrogen atoms of the phenyl group are optionally substituted by the equivalent number of halogen atoms, comprising reducing a compound according to formula VI
- wherein Q is a protecting group or H, and A is OH, a chiral auxiliary group or the group ORp, wherein Rp is a protecting group, and one or more of the hydrogen atoms of the phenyl group are optionally substituted by the equivalent number of halogen atoms, by hydrogenation in the presence of a catalyst.
The process according to claim 1 in which A is a chiral auxiliary group.
Dependencies are inferred from the claim text.