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US 2006/0069269 A1Published application
Novel indazolone derivatives useful as 11b-HSD1 inhibitors
AssigneeHoffmann-La Roche Inc.
InventorsKurt Amrein, Jianping Cai, Robert Goodnow, Daniel Hunziker, Bernd Kuhn, Alexander Mayweg, Werner Neidhart
Life of this patent
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Abstract
Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R7 have the significances given in the description and claims can be used in the form of pharmaceutical compositions.
Claims28
A compound of the formula (I):
- wherein:
- R1 is hydrogen, lower-alkyl, aryl, or aryl-lower-alkyl;
- R2 is aryl, aryl-lower-alkyl, heteroaryl, heteroaryl-lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, fluoro-lower-alkyl, or lower-alkyl, which lower-alkyl is optionally substituted with 1 to 3 substituents selected from the group consisting of OH, CN, halogen, lower-alkoxy and C(O)NR8R9;
- R3 is hydrogen, halogen, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, or fluoro-lower-alkoxy;
- R4 is hydrogen, halogen, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, or fluoro-lower-alkoxy;
- R5 is hydrogen, halogen, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, or fluoro-lower-alkoxy;
- R6 is hydrogen or lower-alkyl;
- R7 is aryl, heteroaryl, fluoro-lower-alkyl, or lower-alkyl, which lower-alkyl is optionally substituted with 1 to 3 substituents selected from the group consisting of OH, CN, halogen, lower-alkoxy and cycloalkyl;
- and
- R8 and R9, independently from each other, are selected from the group consisting of hydrogen and lower-alkyl;
- and pharmaceutically acceptable salts thereof.
8 more elements
Dependencies are inferred from the claim text.