Novel aryl ureido benzoic acid derivatives and their use

An aryl ureido derivative represented by Formula I,

• any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically-acceptable addition salt thereof, wherein
• AC represents an acidic group selected from
• —SO2OH;
• —SO2NH2;
• a group of the formula —(CH2)nCOOH, wherein n is 0, 1, 2 or 3;
• a group of the formula —(CX)OH, wherein
• X represents O or NR″, wherein R″ represents hydrogen or alkyl;
• or
• X together with R′ form a heterocyclic ring;
• and
• a heterocyclic ring of the structure
• R′ represents hydrogen or alkyl;
• or
• R′ and X together form a heterocyclic ring;
• and
• R1 and R2, independently of each another, represents hydrogen, halo, alkyl, cycloalkyl, cycloalkyl-alkyl, haloalkyl, nitro or cyano;
• and
• if one of R1 and R2 represents hydrogen, then the other of R1 and R2 is different from hydrogen;
• and
• AR represents an aromatic mono-, bi- or polycyclic carbocyclic or heterocyclic group, which aromatic group is optionally substituted one or more times with substituents selected from the group consisting of halo, alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, alkynyl, hydroxy, alkoxy, oxo, haloalkyl, nitro, cyan, phenyl or benzyl;
• or
• which aromatic group is optionally substituted with a methylenedioxy group or a higher homolog of the structure —O—(CH2)m—O—, wherein m is 1, 2 or 3.