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US 2006/0069249 A1Published application
16-Member ring metal chelate
AssigneesThe Hong Kong Polytechnic University, Victor Snieckus
InventorsKwok-Yin Wong, Chi Huang, Cheuk-Sang Kwok, Victor Snieckus
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Abstract
Metal chelates are useful for improving the contrast of X-ray, ultrasound, radionuclide and magnetic resonance (MR) images. However, the metal complexes must be stable and inert so that toxicity resulting from dissociation in the body can be minimized. This invention provides 16-member ring metal chelates that can provide a charge balanced metal complex having improved stability, especially for gadolinium(III) and samarium (III).
Claims10
A metal chelate having the Formula I:
- wherein
- R1 is an anionic group having minus one charge;
- and
- R2 is a chemically reactive group capable of forming a linkage with a biomolecule.
1 more element
A method of synthesizing A metal chelate having the Formula I:
- including the steps of:
- reacting compounds of Formula II and Formula III to form a compound of Formula IV
- reacting a molecule having chemically reactive group R2 with the compound of Formula IV to replace the hydrogen on the N—H group of Formula IV;
- replacing the hydrogen on the two O—H groups of Formula IV with a first leaving group L1 to form a compound of Formula V
- replacing one hydrogen of each nitrogen of a compound of Formula VI with a second leaving group L2, and then with a metal alkoxide to replace the terminal hydrogen with the metal to form a compound of Formula VII
- reacting the compounds of Formula V and Formula VII, and then replacing the second leaving groups L2 with R1 groups to form the compound of Formula I.
3 more elements
Dependencies are inferred from the claim text.