Process for producing phosphoroamidite
AssigneeMitsui Chemicals, Inc.
InventorsHironori Komatsu, Mayumi Hiwara
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Abstract
The present invention provides high purity phosphoroamidite products by reducing the amount of impurities of triphosphite which has been additionally produced according to the conventional technique. Phosphoroamidites can be obtained with high purity such that the excess reaction is suppressed by using a reaction activator hardly generating triphosphite. According to the present invention, phosphoroamides can be obtained with high purity, which has heretofore been difficult to suppress the generation of impurities of triphosphite.
Claims15
A method for preparing phosphoroamidite with a reagent of a compound represented by the general formula [1],
- wherein R1 represents an alkyl group having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms substituted by a cyano group or an alkyl group having 1 to 4 carbon atoms substituted by a silyl group;
- and R2 represents an amino group substituted by an alkyl group having 2 to 5 carbon atoms or an alicyclic amino group having 4 to 7 carbon atoms, p1 wherein a substituted tetrazole represented by the general formula [2] is used as a reaction activator,
- wherein R3 represents an alicyclic alkyl group having 1 to 6 carbon atoms, an aryl group substituted by an alkyl group having 1 to 4 carbon atoms or an unsubstituted aryl group.
Dependencies are inferred from the claim text.