Lactam polymer derivatives
AssigneeJohnson & Johnson Vision Care, Inc.
InventorsStephen Arnold, Walter Laredo
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Abstract
Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.
Claims58
A process comprising reacting in a solvent at least one lactam polymer and a reducing agent to form a hydroxyl functionalized lactam polymer derivative.
The process of claim 32 wherein said reactive fluorescent dye is selected from the group consisting of dansyl chloride, dansyl hydrazine, m-dansylaminophenylboronic acid, tetramethylrhodamine-5-carbonyl azide, fluorescein (free acid and sodium salt), fluorescein isothiocyanate (FITC), 5-(4,6-dichlorotriazinyl)aminofluorescein (5-DTAF), fluorescamine, fluorescein-5-carbonyl azide diacetate, 9-anthroylnitrile, 9-anthracene carbonyl chloride, 9-carbazoleacetic acid, carbazole-9-carbonyl chloride, 9-carbazolepropionic acid, 7-diethylaminocoumarin-3-carbonyl azide, 7-methoxycoumarin-3-carbonyl azide and combinations thereof.
A polymer comprising substituted and unsubstituted lactam repeating units and hydroxy alkyl substituted amine repeating units in said polymer's backbone.
A hydrogel formed from a reaction mixture comprising at least one hydrophilic monomer and a lactam component selected from the group consisting of hydroxyl functionalized lactam polymers, reactive lactam polymers, fluorescently labeled lactam polymers and combinations thereof.
Dependencies are inferred from the claim text.