Process for preparing terbinafine by using platinum as catalyst
AssigneeDipharma S.p.A.
InventorsAntonio Tarquini, Graziano Castaldi, Gianluca Galdi, Pietro Allegrini
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Abstract
A process for the preparation of terbinafine, comprising the reaction of a compound of formula (II), or a salt thereof, wherein X is a leaving group, with tert-butylacetylene, in the presence of a platinum catalyst.
Claims13
A process for the preparation of terbinafine, or a pharmaceutically acceptable salt thereof, comprising reacting a compound of formula (II), or a salt thereof,
- wherein X is a leaving group,
- with tert-butylacetylene, in the presence of a platinum catalyst.
Terbinafine, or a pharmaceutically acceptable salt thereof, having a purity equal to or greater than 99.5%.
Terbinafine, or a pharmaceutically acceptable salt thereof, as pure (E)-form.
Terbinafine, or a pharmaceutically acceptable salt thereof, free from catalyst residues.
Dependencies are inferred from the claim text.