Transparent eye drops containing latanoprost
AssigneeSanten Pharmaceutical Co., Ltd.
InventorsHiroyuki Asada, Akio Kimura
Life of this patent
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Abstract
An object of the present invention is to provide better formulations of a latanoprost ophthalmic solution. The present invention provides a clear ophthalmic solution comprising latanoprost as an active ingredient and benzalkonium chloride as a preservative wherein white turbidity due to a change of formulation is prevented by at least one means selected from the following 1) to 3); 1) adding a surfactant, 2) using benzalkonium chloride represented by the formula of [C6H5CH2N(CH3)2R]Cl (wherein R is alkyl having 12 carbon atoms) as the preservative and 3) adding a nonionic tonicity agent as a tonicity agent.
Claims8
A clear ophthalmic solution comprising latanoprost as an active ingredient and benzalkonium chloride as a preservative wherein white turbidity due to a change of formulation is prevented by at least one means selected from the following 1) to 3);
- 1)adding a surfactant,
- 2) using benzalkonium chloride represented by the formula of [C6H5CH2N(CH3)2R]Cl (wherein R is alkyl having 12 carbon atoms) as the preservative and
- 3) adding a nonionic tonicity agent.
A method of preventing white turbidity due to a change of formulation in an ophthalmic solution comprising latanoprost as an active ingredient and benzalkonium chloride as a preservative by at least one means selected from the following 1) to 3);
- 1) adding a surfactant,
- 2) using benzalkonium chloride represented by the formula of [C6H5CH2N(CH3)2R]Cl (wherein R is alkyl having 12 carbon atoms) as the preservative and
- 3) adding a nonionic tonicity agent.
Dependencies are inferred from the claim text.