Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as Huntington's disease, by sodium butyrate chemotherapy
AssigneeU.S. Department of Veterans Affairs
InventorRobert Ferrante
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Abstract
A method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as Huntington's disease, includes administering a histone deacetylase (HDAC) inhibitor in a subject in need thereof. The HDAC inhibitor includes sodium butyrate.
Claims18
A method of ameliorating or abrogating the effects of a neurodegenerative disorder in a subject, comprising:
- administering a histone decaetylase (HDAC) inhibiting agent in a subject in need thereof;
- wherein the HDAC inhibiting agent comprises a butyrate.
A method of preventing neuronal death in a subject having Huntington's disease, comprising:
- administering a histone deacetylase (HDAC) inhibiting agent in a subject in need thereof;
- wherein the HDAC inhibiting agent comprises a butyrate.
A method of treating a subject having Huntington's disease, comprising:
- administering a histone deacetylase (HDAC) inhibiting agent in a subject in need thereof;
- wherein the HDAC inhibiting agent comprises a butyrate.
A method of protecting neural cells in a subject having a neurological disorder, comprising:
- increasing histone acetylation by administering a butyrate in a subject in need thereof.
A method of improving motor performance, gross brain weight and atrophy, striatal neuron atrophy, and/or survival in a subject, comprising:
- administering a histone decaetylase (HDAC) inhibiting agent in a subject in need thereof;
- wherein the HDAC inhibiting agent comprises a butyrate.
Dependencies are inferred from the claim text.