4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

A compound of the formula

• where R1 is independently H, alkyl of 1 to 4 carbons, CH2OR2, or fluoro substituted alkyl of 1 to 4 carbons;
• R2 is independently H, alkyl of 1 to 4 carbons, C(O)R7, carbocyclic aryl or heterocyclic aryl having 1 to 3 heteroatoms independently selected from N, O and S;
• R3 is independently selected from the groups consisting of alkyl of 1 to 4 carbons, alkenyl of 2 to 4 carbons, alkynyl of 2 to 4 carbons, CH2OR2, CH2N(R2)2, CH2CN, C(O)R2, C(O)OR6, SO3R6, SO2N(R2)2, CH2SR2, F, Cl, Br, I, fluoro substituted alkyl of 1 to 4 carbons, CN, N3, NO2, N(R2)2, OR2, SR2;
• p is an integer having the values of 0, 1, 2, or 3;
• R4 and R5 together with the carbons to which they are attached jointly form a carbocyclic or a heterocyclic ring, the heterocyclic ring having 5 or 6 atoms in the ring and 1 to 3 heteroatoms independently selected from N, O and S;
• said carbocyclic or heterocyclic ring jointly formed by R4 and R5 being optionally substituted with 1 to 7 R8 groups;
• R6 is independently H, alkyl of 1 to 4 carbons, carbocyclic aryl or heterocyclic aryl having 1 to 3 heteroatoms independently selected from N, O and S;
• R7 is H or alkyl of 1 to 4 carbons, and R8 is independently selected from the groups consisting of alkyl of 1 to 4 carbons, alkenyl of 2 to 4 carbons, alkynyl of 2 to 4 carbons, CH2OR2, CH2N(R2)2, CH2CN, C(O)R2, C(O)OR6, SO3R6, SO2N(R2)2, CH2SR2, F, Cl, Br, I, fluoro substituted alkyl of 1 to 4 carbons, CN, N3, NO2, N(R2)2, OR2, SR2 or R8 is O or S double bonded to one carbon of said carbocyclic or heterocyclic ring.