Unsubstituted and substituted 4-benzyl-1,3-dihydro-imidazole-2-thiones acting as specific or selective alpha2 adrenergic agonists and methods for using the same

A method comprising administering to a mammal a pharmaceutical composition containing a therapeutically effective dose of a compound for the treatment of chronic pain, visceral pain, neuropathic pain, corneal pain, glaucoma, elevated intraocular pressure, ischemic neuropathies, neurodegenerative diseases, diarrhea, nasal congestion, muscle spasticity, diuresis, withdrawal syndromes, neurodegenerative diseases, optic neuropathy, spinal ischemia, stroke, memory and cognition deficits, attention deficit disorder, psychoses, manic disorders, anxiety, depression, hypertension, congestive heart failure, cardiac ischemia, arthritis, spondylitis, gouty arthritis, osteoarthritis, juvenile arthritis, autoimmune diseases, lupus erythematosus, chronic gastrointestinal inflammations, Crohn's disease, gastritis, irritable bowel syndrome (IBS), functional dyspepsia, ulcerative colitis, or a combination thereof;

• said compound having a structure
• where n is an integer having the values of 0 to 5;
• R1 is independently selected from the group consisting of alkyl of 1 to 4 carbons, alkenyl of 2 to 4 carbons, alkynyl of 2 to 4 carbons, (CH2)mOR2, (CH2)mNR3R4, (CH2)mCN, C(O)R5, C(O)OR5, (CH2)mSO2R5, aryl, heteroaryl, F, Cl, Br, I, fluoroalkyl containing 1 to 4 carbon atoms and 1 to 9 fluoro atoms, fluoroalkoxy containing 1 to 4 carbon atoms and 1 to 9 fluoro atoms, N3 and NO2,
• said heteroaryl having 1 to 3 heteroatoms independently selected from O, N and S, and said aryl and heteroaryl groups being optionally substituted with 1 to 3 radicals selected from the group consisting of alkyl of 1 to 4 carbons, alkenyl of 2 to 4 carbons, alkynyl of 2 to 4 carbons, (CH2)mOR2, (CH2)mNR3R4, (CH2)mCN, C(O)R5, C(O)OR5, (CH2)mSO2R5, fluoroalkyl containing 1 to 4 carbon atoms and 1 to 9 fluoro atoms, fluoroalkoxy containing 1 to 4 carbon atoms and 1 to 9 fluoro atoms, N3 and NO2,
• m is an integer having the values of 0, 1, 2, or 3;
• R2 is H, alkyl of 1 to 4 carbons, C(O)R5, and aryl, or heteroaryl containing 1 to 3 heteroatoms independently selected from O, N and S, and said aryl and heteroaryl groups being optionally substituted with 1 to 3 radicals selected from the group consisting of alkyl of 1 to 4 carbons, alkenyl of 2 to 4 carbons, alkynyl of 2 to 4 carbons, (CH2)mOR2, (CH2)mNR3R4, (CH2)mCN, C(O)R5, C(O)OR5, (CH2)mSO2R5, fluoroalkyl containing 1 to 4 carbon atoms and 1 to 9 fluoro atoms, fluoroalkoxy containing 1 to 4 carbon atoms and 1 to 9 fluoro atoms, N3 and NO2;
• R3 and R4 are independently selected from the group consisting of H, alkyl of 1 to 4 carbons, C(O)R5 and benzyl;
• R5 is independently H, alkyl of 1 to 4 carbons, aryl, or heteroaryl containing 1 to 3 heteroatoms independently selected from O, N and S, and said aryl and heteroaryl groups being optionally substituted with 1 to 3 radicals selected from the group consisting of alkyl of 1 to 4 carbons, alkenyl of 2 to 4 carbons, alkynyl of 2 to 4 carbons, (CH2)mOR2, (CH2)mNR3R4, (CH2)mCN, C(O)R5, C(O)OR5, (CH2)mSO2R5, fluoroalkyl containing 1 to 4 carbon atoms and 1 to 9 fluoro atoms, fluoroalkoxy containing 1 to 4 carbon atoms and 1 to 9 fluoro atoms, N3 and NO2.