N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
OwnerJohn Duncia, Daniel Gardner +1inventors
InventorsJohn Duncia, Daniel Gardner, Joseph Santella
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Abstract
The present application describes N-ureidoalkyl piperidines as modulators of chemokine receptors, or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
Claims13
A compound of formula (I):
- or a pharmaceutically acceptable salt form thereof, wherein
- R1 is selected from methyl;
- and
- R2 is selected from H, methyl, and ethyl.
A method for treating disorders, wherein the disorder is selected from asthma, allergic rhinitis, atopic dermatitis, inflammatory bowel diseases, idiopathic pulmonary fibrosis, bullous pemphigoid, helminthic parasitic infections, allergic colitis, eczema, conjunctivitis, transplantation, familial eosinophilia, eosinophilic cellulitis, eosinophilic pneumonias, eosinophilic fasciitis, eosinophilic gastroenteritis, drug induced eosinophilia, HIV infection, cystic fibrosis, Churg-Strauss syndrome, lymphoma, Hodgkin's disease, and colonic carcinoma.
Dependencies are inferred from the claim text.