Back to results
US 2006/0069122 A1Published application
Chemokine-binding heterocyclic compound salts, and methods of use thereof
AssigneeAnorMED, Inc.
InventorsJason Crawford, Yongbao Zhu, Gang Chen, Ian Baird, Renato Skerlj
Life of this patent
Estimating the term…
Abstract
The present invention relates to chemokine-binding heterocyclic compound salts, methods of use thereof, and methods for preparing the same.
Claims42
A process for preparing a salt of a compound of Formula I
- comprising contacting a compound of formula I in a solvent with an acid to obtain a salt of a compound of formula I, wherein said salt is citrate, edetate, lactate, maleate, mandelate, mesylate, terephthalate, substituted or unsubstituted benzoate, orotate, substituted benzenesulfonate, naphthoate, napsylate, or tosylate.
A pharmaceutically acceptable salt of a compound of Formula I
- wherein said salt is citrate, edetate, lactate, maleate, mandelate, mesylate, terphthalate, substituted or unsubstituted benzoate, orotate, substituted benzenesulfonate, naphthoate, napsylate, or tosylate.
A benzoate salt of a compound of Formula I
- having less hydroscopicity than the hydrobromide or hydrochloric salt of said compound of Formula I.
The salt of clam 31, wherein said salt has an improved stability as compared to the free base at about 30 degrees Celsius and above;
- at about 40 degrees Celsius and above;
- or at about 70 degrees Celsius and above.
Dependencies are inferred from the claim text.