Analgesic compositions containing buprenorphine
AssigneeReckitt Benckiser Healthcare (UK) Limited, a United Kingdom corporation
InventorsChristopher Chapleo, Nicolas Varey, Keith McCormack
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Abstract
An analgesic composition in parenteral unit dosage form or in a unit dosage form suitable for delivery via the mucosa comprising an amount of buprenorphine which is less than the clinical dose required to achieve pain relief and an amount of naloxone such that the ratio by weight of buprenorphine to naloxone is in the range of from 12.5:1 to 27.5:1, or an amount of naltrexone or nalmefene such that the ratio by weight of buprenorphine to naltrexone or nalmefene is in the range of from 12.5:1 to 22.5:1. The analgesic action of the buprenorphine is potentiated by the low dose of naloxone, naltrexone or nalmefene.
Claims5
An analgesic composition in parenteral unit dosage form or in a unit dosage form suitable for delivery via the mucosa comprising an amount of buprenorphine which is less than the clinical dose required to achieve pain relief and an amount of naltrexone such that the ratio by weight of buprenorphine to naltrexone is in the range of from 12.5:1 to 22.5:1, whereby the analgesic action of the buprenorphine is potentiated by the low dose of naltrexone.
Dependencies are inferred from the claim text.