Methods for regulating neurotransmitter systems by inducing counteradaptations
OwnerAlexander Michalowinventor
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Abstract
The present invention relates to methods for regulating neurotransmitter systems by inducing a counteradaptation response. According to one embodiment of the invention, a method for regulating a neurotransmitter includes the step of repeatedly administering a ligand for a receptor in the neurotransmitter system, with a ratio of administration half-life to period between administrations of no greater than 1/2. The methods of the present invention may be used to address a whole host of undesirable mental and neurological conditions.
Claims195
A method of regulating a neurotransmitter system by inducing a counteradaptation in a patient, the neurotransmitter system including a type of receptor linked to an undesirable mental or neurological condition, the method comprising the step of:
- repeatedly administering to the patient a ligand for the type of receptor, each administration having an administration half-life, thereby causing the ligand to bind receptors of that type during a first time period associated with each administration, thereby inducing a counteradaptation,
- wherein the counteradaptation causes the regulation of the neurotransmitter system, and
- wherein the ratio of the administration half-life to the period between administrations is no greater than 1/2.
A method of inducing a regulation of a neurotransmitter system in a patient, the neurotransmitter system including a type of receptor linked to an undesirable mental or neurological condition, the method comprising the steps of:
- inducing a counteradaptation by giving the patient a ligand for the type of receptor;
- then
- repeatedly administering to the patient a ligand for the type of receptor, each administration having an administration half-life, thereby causing the ligand to bind receptors of that type during a first time period associated with each administration, thereby maintaining or improving the counteradaptation,
- wherein the counteradaptation causes the regulation of the neurotransmitter system, and
- wherein the ratio of the administration half-life to the period between administrations is no greater than 1/2.
The method of any one of claims 1-16, wherein each administration has a second time period associated therewith, the second time period being subsequent to the first time period associated with the administration, and wherein a substantial fraction of the receptors remain unbound to the ligand during each second time period.
The method of any one of 81-114, wherein a mu and/or delta opiate receptor agonist is not administered during the first time period associated with each administration.
The method of any one of 158-164, wherein a serotonin post-synaptic receptor agonist is not administered during the first time period associated with each administration.
A method of inducing a regulation of a neurotransmitter system, the neurotransmitter system including a type of receptors linked to an undesirable mental or neurological condition, the method comprising the step of:
- repeatedly administering to the patient a ligand for the type of receptor, each administration having an administration half-life, thereby causing the ligand to bind a substantial fraction of receptors of that type during a first time period associated with each administration, thereby inducing a counteradaptation,
- wherein the counteradaptation causes the regulation of the neurotransmitter system during a second time period associated with each administration, the second time period being subsequent to the first time period.
Dependencies are inferred from the claim text.