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OwnerAjay Bhatnagar, Dean Evans +2inventors
InventorsAjay Bhatnagar, Dean Evans, Jurg Gasser, Jonathan Green
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The present invention provides a combination for the treatment of a disease or condition which responds to aromatase inhibition, in particular a proliferative disease, especially a malignant disease such as breast cancer or similar soft tissue endocrine-sensitive cancer, most preferably breast cancer, comprising an aromatase inhibitor and a bisphosphonate for simultaneous, concurrent, separate or sequential use in the prevention of bone loss which is caused by the treatment with an aromatase inhibitor. Also provided is a method of treating a patient suffering from a disease or condition which responds to aromatase inhibition comprising administering to the patient an effective amount of a bisphosphonate and an effective amount of an aromatase inhibitor.
A combination which comprises (a) an aromatase inhibitor and (b) a bisphosphonate in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt, for simultaneous, concurrent, separate or sequential use in the prevention of bone loss which is caused by the treatment with an aromatase inhibitor of a disease or condition which responds to aromatase inhibition.
A method of treating a patient suffering from a disease or condition which responds to aromatase inhibition comprising administering to the patient an effective amount of a bisphosphonate and an effective amount of an aromatase inhibitor, especially with the proviso that the patient is not additionally treated with a chemotherapeutic agent.
4-8. (canceled)
A package comprising a bisphosphonate together with instructions for use in combination with an aromatase inhibitor for treatment of a disease or condition which responds to aromatase inhibition, especially with the proviso that the disease or condition is not additionally treated with a chemotherapeutic agent, or
A package comprising a bisphosphonate together with instructions for use in combination with an aromatase inhibitor for prevention of bone loss which is caused by the treatment with an aromatase inhibitor of a disease or condition which responds to aromatase inhibition, or
A method of preventing bone loss in a patient suffering from an estrogen dependent disorder and receiving an aromatase inhibitor comprising administering to said patient an effective amount of a bisphosphonate.
A method of preventing cancer treatment-related bone loss in a postmenopausal woman with ER+ and/or PR+ breast cancer receiving an aromatase inhibitor as adjuvant therapy comprising administering to said postmenopausal woman an effective amount of a bisphosphonate.
A method of treating or preventing bone loss caused by the treatment with an aromatase inhibitor of a disease or condition which responds to aromatase inhibition comprising administering to a patient in need of such treatment or prevention an effective amount of an aromatase inhibitor and an effective amount of a bisphosphonate.
Dependencies are inferred from the claim text.