Loading patent…
OwnerSophia Khaldoyanidiinventor
Estimating the term…
Hyaluronic Acid (HA) is an essential component of tissue extracellular matrices that contributes to the architecture of stem cell niches, which determine the fate of stem cells. Decreased levels of HA are found in subjects experiencing a variety of pathological conditions, as well as in subjects receiving a variety of therapeutic interventions, for example, chemotherapy or radiotherapy, to treat pathological conditions. The use of HA to reconstitute a tissue extracellular matrix partially or completely depleted of HA is described. More particularly, described herein is the use of exogenous forms of HA as an adjuvant in the restoration of the local tissue specific stem cell microenvironment to enhance stem cell recovery or engraftment and thus tissue recovery and remodeling following stem cell transplantation or other therapies. The effect of HA on hematopoietic stem cells is illustrative of the invention. Mice having severe bone marrow hypoplasia, and pancytopenia resulting from treatment with 5-fluorouracil recovered more rapidly if treated with HA. Similarly, mice transplanted with hematopoietic stem cells following lethal irradiation exhibited enhanced recovery of peripheral blood cell counts when treated with HA as an adjuvant therapy compared to control mice transplanted with hematopoietic stem cells without adjuvant therapy.
A method of treating a pathological condition in a subject that is associated with decreased levels of hyaluronic acid in a microenviromnental niche of a tissue or organ comprising administration to the subject of an effective dose of hyaluronic acid, or a pharmaceutically acceptable salt thereof to facilitate stem cell homing.
A method for treating a subject to improve the engraftment of implanted or transplanted stem cells comprising the administration to the subject of an effective dose of hyaluronic acid or a pharmaceutically acceptable salt thereof.
In a method of treating a subject with a drug or radiation that results in bone marrow dysfunction, the improvement comprising treating the subject having the bone marrow dysfunction with an effective amount of hyaluronic acid, or a pharmaceutically acceptable salt thereof to restore the microenvironmental niche for stem cell homing.
A method for improving the recovery of the number of stem cells and their functions in a subject having a depleted population of stem cells as the result of a pathological condition or of a therapy which depletes the stem cell population or proper function of stem cells comprising administering to the patient an effective amount of hyaluronic acid, or a pharmaceutically acceptable salt thereof to facilitate homing of the stem cells.
A method for culturing stem cells, the improvement comprising including hyaluronic acid in the culture medium to facilitate homing of the cultured cells to a microenvironmental niche.
A method for facilitating homing activity of stem cells in a subject comprising the step of providing hyaluronic acid wherein the hyaluronic acid functions to home stem cells to a microenviromnental niche.
Dependencies are inferred from the claim text.