Methods and reagents related to foxo
AssigneePresident and Fellows of Harvard College
InventorsAlfred Goldberg, Stewart Lecker, Marco Sandri
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Abstract
The present invention relates to regulating the activity of Foxo and prevention and treatment of diseases associated with aberrant Foxo activity.
Claims13
A method for treating a condition related to aberrant foxo activity by modulating the phosphorylation of Foxo;
- stimulating Foxo phosphorylation, reducing Foxo expression;
- or reducing Foxo activity.
A diagnostic or prognostic method of a condition related to aberrant Foxo activity involving measuring the level of Foxo phosphorylation.
A microarray chip comprising the plurality of cDNA sequences of genes of claim 12.
A method for determining the difference between levels of expression of a plurality of genes characteristic of a condition related to aberrant Foxo activity in a cell and reference levels of expression of the genes, comprising
- providing RNA from a cell;
- determining levels of RNA of a plurality of genes characteristic of the condition related to aberrant Foxo activity including a plurality of genes selected from the group consisting of those genes listed in Supplementary Tables 1 or 2 of Example 1 to obtain the levels of expression of the plurality of genes in the cell;
- and
- comparing the levels of expression of the plurality of genes in the cell to a set of reference levels of expression of the genes,
- to thereby determine the difference between levels of expression of the plurality of genes characteristic of the condition related to aberrant Foxo activity in the cell and reference levels of expression of the genes.
Dependencies are inferred from the claim text.