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US 2006/0069034 A1Published application
Antipathogenic benzamide compounds
AssigneeGeneSoft Pharmaceuticals, Inc.
InventorsRoland Burli, Jacob Kaizerman, Peter Jones
Life of this patent
Estimating the term…
Abstract
Antipathogenic benzamide compounds having the formula wherein at least one of the R1 groups is F, Cl, CN or CF3 and R2, R3, Y, Z, m, and n are as defined herein.
Claims26
A compound according to the formula
- and the pharmaceutically acceptable salts thereof,
- wherein
- each R1is independently H, F, Cl, CN, CF3, OH, N(R2)2, OR2 or a substituted or unsubstituted (C1-C12)alkyl group, or a substituted or unsubstituted (C1-C12)heteroalkyl group, with the proviso that at least one R1 is F, Cl, CN, OCF3, OCF2H, or CF3;
- each R2 and R3 is independently H, a substituted or unsubstituted (C1-C12)alkyl group, or a substituted or unsubstituted (C1-C12)heteroalkyl group;
- m is an integer from 1 to 25, inclusive;
- each Y is independently a branched or unbranched, substituted or unsubstituted (C1-C5)alklylene group or a substituted or unsubstituted, aromatic or heteroaromatic ring system, wherein the ring system has at least one of a 5- or 6-member aromatic or heteroaromatic ring or fused 6,6 or 6,5 aromatic or heteroaromatic rings, with the proviso that at least one Y is a substituted or unsubstituted 5-member heteroaromatic ring;
- Z is O or N;
- and
- n is 1 if Z is O and 2if Z is N;
- said compound having at least one basic group having a pkb of 12 or less or a quaternized nitrogen group.
7 more elements
A compound of the formula
- and the pharmaceutically acceptable salts thereof,
- wherein
- m is an integer from 1 to 25, inclusive;
- each moiety —(NR3—Y—CO)— is independently selected from the group consisting of
- (a) moieties M1having the formula
- wherein one of X1, X2, and X3 is a ring vertex selected from the group consisting of —O—, —S—, and —NR2—, and the other two of X1, X2, and X3 are ring vertices selected from the group consisting of ═N— and ═CR4—;
- (b) moieties M2 having the formula
- wherein x is 0 or 1 and each R15 is independently H, OH, NH2, or F;
- (c) moieties M3 having the formula
- wherein each L is independently a divalent moiety separating —NH— and —(C═O)— by 3 or 4 atoms;
- and
- (d) moieties M4 having the formula
- with the proviso that at least one moiety —NR3—Y—CO)— is a moiety M1;
- Z is O or N;
- n is 1 if Z is O and 2if Z is N;
- each R1is independently H, F, Cl, CN, CF3, OH, N(R2)2, OR2 or a substituted or unsubstituted (C1-C12)alkyl group, or a substituted or unsubstituted (C1-C12)heteroalkyl group, with the proviso that at least one R1 is F, Cl, CN or CF3;
- each R2 and R3 is independently H, a substituted or unsubstituted (C1-C12)alkyl group, or a substituted or unsubstituted (C1-C12)heteroalkyl group;
- each R4 is independently H, F, Cl, Br, I, CN, OH, NO2, NH2, a substituted or unsubstituted (C1-C12)alkyl group, or a substituted or unsubstituted (C1-C12)heteroalkyl group;
- said compound having at least one basic group having a pKb of 12 or less or a quaternized nitrogen group.
16 more elements
Dependencies are inferred from the claim text.