Use of poly-amminopyrrolecarboxamides alone or in combination with a cyclodextrin in the prophylaxis and treatment of animal parasitosis

A method for prophylaxis and/or treatment of endoparasitosis in an animal, comprising administration to the animal of an effective amount of a compound having the following formula (I):

• wherein:
• n is 0 or an integer comprised between 1 and 5;
• R is a group R2—X—C(=Z)-NH—, in which X represents a simple chemical bond, an aromatic or heteroaromatic radical, Z represents an oxygen atom or the NH group;
• and:
• if X is a simple chemical bond, R2 is an hydrogen atom, an alkyl, dialkylaminoalkyl, alkenyl, cycloalkyl, arylalkyl, arylalkenyl, haloalkyl, or an aromatic or heteroaromatic radical;
• if X is an aromatic or heteroaromatic radical, R2 is nitro, amino or formylamino;
• or:
• R is a group R3—C(=Z)-, in which Z represents an oxygen atom or the NH group, and R3 represents a hydrogen atom, the —OR4 or —NR5R6 group, and where:
• R4 is chosen from the group consisting of a hydrogen atom, an alkyl, cycloalkyl, arylalkyl, or an aromatic radical;
• R5 and R6, either the same or different, are chosen from the group consisting of a hydrogen atom, an alkyl, cycloalkyl, arylalkyl, aromatic or heterocyclic radical, optionally substituted with a formylamino or a carbamoyl group;
• or
• R5 and R6, joined together form an alkylene group, or the group —(CH2)2—O—(CH2)2— or the group —(CH2)2—NH—(CH2)2—;
• A represents a simple chemical bond or the group —CO—NH—Y—, wherein Y is an alkylene or aromatic radical;
• R1 is chosen from the group consisting of CH2N(CH3)2, —COOR4, —B—NR5R6, —C(═NH)—NH2, a heterocyclic radical containing nitrogen, wherein:
• R4, R5 and R6 are as defined above, B represents a simple chemical bond or the —C═O group, and:
• when R1 is —B—NR5R6, and B is a simple chemical bond, or when R1 is a heterocyclic radical, A is not a chemical bond;
• or a pharmaceutical acceptable salt thereof.