Apolipoprotein A1 mimetics and uses thereof
AssigneeTrustees of Tufts College
InventorWilliam Bachovchin
Life of this patent
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Abstract
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also provides pharmaceutical compositions and methods of treatment for elevated levels of plasma cholesterol.
Claims18
A peptidomimetic with a substantially similar three-dimensional conformation as a peptide comprising the D-amino acid sequence F-A-E-K-F-K-E-A-V-K-D-Y-F-A-K-F-W-D (SEQ ID NO:3).
A peptidomimetic for treatment of elevated levels of plasma cholesterol in a mammal, wherein the peptidomimetic has a substantially similar three-dimensional conformation as a peptide comprising a D-amino acid sequence Ac-F-A-E-K-F-K-E-A-V-K-D-Y-F-A-K-F-W-D-NH2 (SEQ ID NO:2).
The peptidomimetic of claim 7, wherein the peptidomimetic further comprises a protecting group coupled to the amino or carboxy terminus of the peptidomimetic.
Dependencies are inferred from the claim text.