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US 2006/0069018 A1Published application
Endogenous repair factor production promoters
AssigneeOno Pharmaceutical Co., Ltd.
InventorsYoshiki Sakai, Akio Nishiura, Teppei Ogata
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AssigneeOno Pharmaceutical Co., Ltd.
InventorsYoshiki Sakai, Akio Nishiura, Teppei Ogata
Estimating the term…
It relates to an endogenous repair factor production accelerator which comprises one or at least two selected from prostaglandin (PG) I2 agonist, EP2 agonist and EP4 agonist. Since prostaglandin (PG) I2 agonist, EP2 agonist or EP4 agonist has various endogenous repair factor production accelerating action, angiogenesis acceleration action and stem cell differentiation induction action, it is useful as preventive and/or therapeutic agents for ischemic organ diseases (e.g., arteriosclerosis obliterans, Buerger disease, Raynaud disease, myocardial infarction, angina pectoris, diabetic neuropathy, spinal canal stenosis, cerebrovascular accidents, cerebral infarction, pulmonary hypertension, bone fracture, Alzheimer disease, etc.) and various cell and organ diseases.
-16. (canceled)
A method for accelerating production of an endogenous repair factor in a mammal, which comprises administering to a mammal an effective amount of one or at least two selected from a PGI2 agonist, an EP2 agonist and an EP4 agonist.
A method for preventing and/or treating organ diseases in a mammal, which comprises administering to a mammal an effective amount of one or at least two selected from a PGI2 agonist, an EP2 agonist and an EP4 agonist.
(canceled)
(canceled)
A pharmaceutical composition which comprises the endogenous repair factor production accelerator comprising one or least two selected from a PGI2 agonist, an EP2 agonist and an EP4 agonist in combination with one or at least two selected from an anti-thrombus agent, a circulation improving agent, a bronchial smooth muscle dilator, an anti-inflammatory drug, a local anesthetic, an analgesic, a bone cement, an joint lubricant, a PG derivative, an endogenous repair factor protein, an endogenous repair factor gene and a stem cell.
Dependencies are inferred from the claim text.