Taspase1 and methods of use
OwnerJames Hsieh, Stanley Korsmeyer +2inventors
InventorsJames Hsieh, Stanley Korsmeyer, Susan Korsmeyer, Emily Cheng
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Abstract
A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the MLL protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.
Claims41
An isolated polypeptide comprising an amino acid sequence which is at least about 80% identical to the amino acid sequence of SEQ ID NO:1.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:1, wherein up to 20 amino acids are substituted.
An isolated polypeptide encoded by a nucleic acid that hybridizes under high stringency conditions to the nucleic acid of SEQ ID NO:2.
Dependencies are inferred from the claim text.