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US 2006/0068476 A1Published application
Method for the production by fermentation of sulphur-containing fine chemicals (metf)
AssigneeBASF SE
InventorsBurkhard Kroger, Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Hafner
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Abstract
The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metF) gene.
Claims16
A method for the fermentative production of at least one sulfur-containing fine chemical, which comprises the following steps:
- a). fermentation of a coryneform bacteria culture producing the desired sulfur-containing fine chemical, the coryneform bacteria expressing at least one heterologous nucleotide sequence which codes for a protein with methylenetetrahydrofolate reductase (metF) activity;
- b). concentration of the sulfur-containing fine chemical in the medium or in the bacterial cells, and
- c). isolation of the sulfur-containing fine chemical.
A method for producing an L-methionine-containing animal feed additive from fermentation broths, which comprises the following steps:
- a) culturing and fermentation of an L-methionine-producing microorganism in a fermentation medium;
- b) removal of water from the L-methionine-containing fermentation broth;
- c) removal of from 0 to 100% by weight of the biomass formed during fermentation;
- and
- d) drying of the fermentation broth obtained according to b) and/or c), in order to obtain the animal feed additive in the desired powder or granule form.
2 more elements
Dependencies are inferred from the claim text.