Natural killer cell activating factor ii
AssigneeHuman Genome Sciences, Inc.
InventorsJian Ni, Haodong Li, Guo-Liang Yu, Reiner Gentz
Life of this patent
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Abstract
The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
Claims47
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) amino acid residues −17 to +208 of SEQ ID NO:2;
- (b) amino acid residues −16 to +208 of SEQ ID) NO:2;
- (c) amino acid residues 1 to 208 of SEQ ID NO:2;
- and
- (d) amino acid residues 4 to 208 of SEQ ID NO:2.
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) an amino acid sequence of the full-length polypeptide encoded by the cDNA in ATCC Deposit No. 97465;
- (b) an amino acid sequence of the full-length polypeptide, excluding the N-terminal methionine residue, encoded by the cDNA in ATCC Deposit No. 97465;
- and
- (c) an amino acid sequence of the mature polypeptide encoded by the cDNA in ATCC Deposit No. 97465.
An isolated protein comprising a first amino acid sequence 90% or more identical to a second amino acid sequence selected from the group consisting of:
- (a) amino acid residues −17 to +208 of SEQ ID NO:2;
- (b) amino acid residues −16 to +208 of SEQ III NO:2;
- (c) amino acid residues 1 to 208 of SEQ ID NO:2;
- and
- (d) amino acid residues 4 to 208 of SEQ ID NO:2,
- wherein said Protein inhibits the growth of leukemia cells.
37-67. (canceled)
An isolated protein consisting of at least 30 contiguous amino acid residues of SEQ ID NO:2, wherein said protein inhibits the growth of leukemia cells.
77-85. (canceled)
Dependencies are inferred from the claim text.