GABA detection methods and applications
OwnerSeok Yim, Bruce Dunninventors
Life of this patent
Estimating the term…
Abstract
Disclosed herein are silica glass sensors comprising more than one active biological material in a single sol-gel layer. The silica glass sensors may be used to assay complex biological mechanisms in cells and tissues cultivated thereon. Also disclosed are silica glass sensors having GABA-T, SSADH, or both, for detecting GAD, GABA, or SSA.
Claims17
A porous, transparent sol-gel glass having two or more active biological agents entrapped therein.
A method for assaying a test sample for a substance which reacts with or whose reaction is catalyzed by an active biological material which comprises
- contacting a porous, transparent sol-gel glass having the biological material entrapped therein into contact with the test sample;
- and
- observing any change in the optical characteristics of the porous, transparent sol-gel glass.
An assay for a substrate involved in the γ-aminobutyric acid (GABA) pathway in a sample which comprises contacting the sample with an enzyme for the substrate and observing conversion of the substrate.
Dependencies are inferred from the claim text.