Ucp4
AssigneeGenentech, Inc.
InventorsSean Adams, James Pan, Alan Zhong
Life of this patent
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Abstract
The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins (“UCPs”) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
Claims15
An isolated nucleic acid molecule comprising (a) a DNA molecule encoding a UCP4 polypeptide comprising the sequence of amino acid residues from about 1 to about 323 of FIG. 1 (SEQ ID NO:
- 1), or (b) the complement of the DNA molecule of (a).
An isolated nucleic acid molecule comprising DNA encoding a UCP4 polypeptide, wherein said DNA hybridizes under moderately stringent conditions to the complement of the nucleic acid comprising nucleotides from about 40 to about 1011 of FIG. 2 (SEQ ID NO:
- 2).
An isolated nucleic acid molecule comprising (a) a DNA molecule encoding the same mature polypeptide encoded by the cDNA in ATCC Deposit No. 203134 (DNA 77568-1626) or (b) the complement of the DNA molecule of (a).
An isolated nucleic acid molecule comprising (a) DNA encoding a polypeptide having at least an 80% sequence identity to the sequence of amino acid residues from about 1 to about 323 of FIG. 1 (SEQ ID NO:
- 1), wherein said encoded polypeptide increases or decreases mitochondrial membrane potential or metabolic rate, or (b) the complement of the DNA of (a).
An isolated nucleic acid molecule comprising (a) DNA encoding a polypeptide scoring at least 80% positives when compared to the sequence of amino acid residues from about 1 to about 323 of FIG. 1 (SEQ ID NO:
- 1), wherein said encoded polypeptide increases or decreases mitochondrial membrane potential or metabolic rate, or (b) the complement of the DNA of (a).
Dependencies are inferred from the claim text.