Method for screening cells and method for detecting oral carcinoma cells
AssigneeCanon Kabushiki Kaisha
InventorsNobuko Yamamoto, Kohsuke Sasaki
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Abstract
The present invention provides a method of detecting oral carcinoma cells with high accuracy, and a method of making possible early detection of oral carcinoma or discrimination between a precancerous lesion and an early cancer in diagnosis of oral carcinoma. The methods are achieved by screening cells for oral carcinoma or precancerous lesion by measuring a DNA copy number in whole chromosomes or a part thereof in a sample, wherein chromosomal regions for which said copy number is measured comprise at least one region selected from the group consisting of: a 22-23 region in the q arm of Chromosome 8, a 14-21 region in the p arm of Chromosome 3 and a 12-22 region in the p arm of Chromosome 5.
Claims9
A method for screening cells for oral carcinoma or precancerous lesion by measuring a DNA copy number in whole chromosomes or a part thereof in a sample,
- wherein chromosomal regions for which said copy number is measured comprise at least one region selected from the group consisting of:
- a 22-23 region in the q arm of Chromosome 8, a 14-21 region in the p arm of Chromosome 3 and a 12-22 region in the p arm of Chromosome 5.
A method for detecting oral carcinoma cells, wherein a chromosomal DNA copy number is measured and the region 14-21 of the p arm of Chromosome 3 having a lower copy number than in normal healthy people is detected.
A method for detecting oral carcinoma cells, wherein a chromosomal DNA copy number is measured and the region 12-22 of the q arm of Chromosome 5 having a lower copy number than in normal healthy people is detected.
Dependencies are inferred from the claim text.