Identification of genetic markers associated with parkinson disease
AssigneeDuke University
InventorsJeffery Vance, Yi-Ju Li, Margaret Pericak-Vance, Eden Martin, William Scott, Michael Hauser, Jeffrey Stajich, Sofia Oliveira, Joelle van der Walt
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Abstract
The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.
Claims4
A method of identifying a subject as having Parkinson disease and/or having an earlier or later age of developing Parkinson disease and/or having an increased risk of developing Parkinson disease, comprising detecting in the subject the presence of a single nucleotide polymorphism in the eukaryotic translation initiation factor EIF2B3 gene, wherein the single nucleotide polymorphism is correlated with Parkinson disease and/or an earlier or later age of developing Parkinson disease and/or an increased risk of developing Parkinson disease, thereby identifying the subject as having Parkinson disease and/or having an earlier or later age of developing Parkinson disease and/or having an increased risk of developing Parkinson disease.
A method of identifying a subject as having Parkinson disease and/or having an increased risk of developing Parkinson disease and/or having an earlier or later age of developing Parkinson disease, comprising detecting in the subject the presence of a haplotype in the EIF2B3 gene of the subject comprising the following single nucleotide polymorphisms:
- rs263977_C (SNP 59_C),
- rs263978_C (SNP 60_C),
- rs546354_G (SNP 64_G),
- rs566063_T (SNP 65_T), and
- rs364482_G (SNP 66_G).
A method of identifying a subject as having Parkinson disease and/or having an increased risk of developing Parkinson disease and/or having an earlier or later age of developing Parkinson disease, comprising detecting in the subject the presence of a haplotype in the EIF2B3 gene of the subject comprising the following single nucleotide polymorphisms:
- rs263977_A (SNP 59_A),
- rs263978_C (SNP 60_C),
- rs546354_A (SNP 64_A),
- rs566063_T (SNP 65_T), and
- rs364482_G (SNP 66_G).
Dependencies are inferred from the claim text.