Non-adhesive elastic gelatin matrices
AssigneeCovalon Technologies Inc.
InventorsValerio DiTizio, Frank DiCosmo, Yuehua Xiao
Life of this patent
Estimating the term…
Abstract
The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.
Claims45
An elastic protein matrix comprising;
- one or more proteins;
- one or more biocompatible polymers;
- and
- one or more cross-linking agents,
- wherein said matrix is substantially non-adhesive.
An elastic gelatin matrix composition, the matrix composition comprising a mixture of;
- collagen and/or gelatin;
- one or more biocompatible polymers;
- one or more cross-linking agents;
- solvent;
- and
- optional plasticizer.
A method for making a substantially non-adhesive elastic gelatin matrix, the method comprising:
- lyophilizing a frozen solution comprising at least one protein, at least one biocompatible polymer and at least one cross-linking agent for a time effective to substantially remove the solvent.
A method for making a non-adhesive elastic gelatin matrix, the method comprising:
- (a) heating a protein solution comprising collagen and/or gelatin;
- (b) adding one or more biocompatible polymers to (a);
- (c) adding at least one cross-linking agent to (b);
- (d) cooling (c) and lyophilizing.
Dependencies are inferred from the claim text.