Lyophilized pharmaceutical compositions
OwnerKetan Amin, Rose-Marie Dannenfelser +2inventors
InventorsKetan Amin, Rose-Marie Dannenfelser, Joseph Zielinski, Barbara Wang
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Abstract
Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus.
Claims24
A pharmaceutical composition comprising:
- (a) a therapeutic compound;
- (b) an aqueous solvent;
- (c) a nonvolatile cosolvent;
- and
- (d) a bulking agent.
A process of making a pharmaceutically acceptable cake comprising the steps of:
- (a) forming a solution comprising a therapeutic compound, an aqueous solvent, a nonvolatile cosolvent and a bulking agent, said solution being free of a volatile solvent;
- and
- (b) lyophilizing said solution to form a pharmaceutically acceptable cake.
A pharmaceutically acceptable cake comprising:
- (a) a poorly water-soluble therapeutic compound;
- (b) a nonvolatile cosolvent, said nonvolatile cosolvent comprising from about 5% to about 80% by weight of the cake;
- and
- (c) a bulking agent, said bulking agent comprising from about 10% to about 80% % by weight of the cake.
Dependencies are inferred from the claim text.