Phospholipid complexes of lexitropsins, their preparation and use in therapeutic formulations

A phospholipidic preparation consisting in a release system and a lexitropsin of general formula I

• in which R1 is a functional group, preferably a basic one such as a simple or substituted amidine, a secondary or tertiary amine, a quaternary ammonium group, a simple or substituted guanidine, selected from:
• —C(NH)NH2, —C(NH)NHR3, —NH2, NHR3—N(R3)2, —NR3R4, —NH—C(NH)NH2, —NH—C(NH)NHR3, —N(CH2)4, —N3)3+
• whereas R2 represents an aliphatic, aromatic, or arylaliphatic acylic group, also if substituted with atomic groups containing one or more heteroatoms such as atoms of oxygen, nitrogen, or R2 represents a sequence of one or more residues of 1-methyl-4-aminopyrrole-2-carboxylic acid, acylated or not acylated at the N-terminus, also terminating with a residue of 1-methyl-4-carboxamidopyrrole-2-carboxylic acid or with a residue of analogue aminoacids derived from an heterocycle different from pyrrole selected from furane, imidazole, thiophene, thiazole, or derived from benzene, pyridine, a diazine, pyrimidine, substituted or not at the terminal amino group with an acylic group, or containing, in place of the free or substituted amino group a carboxamido group, and R3 or R4 are equal or different lower alkyl groups C1 to C4,
• the release system being a liposome, a micelle, a nanoparticle, a phospholipidic complex or a supramolecular phospholipidic structure able to incorporate a compound of general structure I in stable and reversible form.