Bioactive agent release coating
AssigneeSurModics, Inc.
InventorsStephen Chudzik, Aron Anderson, Ralph Chappa, Timothy Kloke
Life of this patent
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Abstract
A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
Claims25
A method of adjusting the rate of release of one or more bioactive agents from a medical device comprising;
- providing a medical device having one or more surfaces;
- applying a mixture to the one or more surfaces, the mixture including hydrophobic polymers in combination with one or more bioactive agents;
- and
- adjusting the relative concentrations of hydrophobic polymers in the mixture to control the rate of release of the bioactive agent.
A combination comprising:
- a medical device having one or more surfaces;
- a mixture carried on the one or more surfaces, the mixture including complementary hydrophobic polymers in combination with one or more bioactive agents, wherein individual hydrophobic polymer concentrations in the mixture are between about 0.05 and about 70 weight percent.
A combination comprising:
- a stent having one or more surfaces;
- a mixture carried on the one or more surfaces, the mixture including a plurality of polymers, including a first polymer component comprising a poly(alkyl)(meth)acrylate and a second polymer component comprising a poly(ethylene-co-vinyl acetate) in combination with one or more bioactive agents, wherein the first polymer and the second polymer concentrations in the mixture are each between about 0.05 and about 70 weight percent.
A combination comprising:
- a medical device having one or more surfaces;
- a mixture carried on the one or more surfaces, the mixture consisting essentially of a first hydrophobic polymer and a second hydrophobic polymer and a bioactive agent, wherein the first hydrophobic polymer and the second hydrophobic polymer each have a concentration in the mixture between about 0.05 and about 70 weight percent.
Dependencies are inferred from the claim text.